Preparation and In vitro/Ex vivo Evaluation of Nanoemulsion-Based in Situ Gel for Intranasal Delivery of Lasmiditan

• Main Authors: Saba Abdulhadi Jaber (Author), Nawal Ayash Rajab (Author)
• 格式: 圖書
• 出版: College of Pharmacy University of Baghdad, 2024-09-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Lasmiditan (LAS) was formulated as a nanoemulsion based in situ gel (NEIG)with the aim of improving its oral bioavailability via application intranasally. The solubility of LAS in oils, emulsifiers, and co-emulsifiers was determined to identify nanoemulsion (NE)components. Phase diagrams were construc...