Effects of the Local Bone Renin-Angiotensin System on Titanium-Particle-Induced Periprosthetic Osteolysis

• Main Authors: Zhiping Zhao (Author), Changyao Wang (Author), Yingxing Xu (Author), Xiangyu Wang (Author), Bin Jia (Author), Tengbo Yu (Author), Yingzhen Wang (Author), Yongtao Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Wear particles may induce osteoclast formation and osteoblast inhibition that lead to periprosthetic osteolysis (PPOL) and subsequent aseptic loosening, which is the primary reason for total joint arthroplasty failure. Local bone renin-angiotensin system (RAS) has been found to participate in the pa...