ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

• Main Authors: Hassan Dariushnejad (Author), Nosratallah Zarghami (Author), Mohammad Rahmati (Author), Samaneh Ghasemali (Author), Zohreh Sadeghi (Author), Zahra Davoodi (Author), Hossein Jafari Tekab (Author), Masoud Gandomkar Ghalhar (Author)
• Format: Book
• Published: Tabriz University of Medical Sciences, 2014-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Intensive chemotherapy with daunorubicin (DNR) is associated with serious side effects in acute myeloid leukemia (AML) patients. In this study the effect of small-molecule BH3-mimetic, ABT-737, on the sensitivity of HL60 and U937 AML cell lines was investigated. Methods: The cytotoxic effec...