ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

• Váldodahkkit: Hassan Dariushnejad (Dahkki), Nosratallah Zarghami (Dahkki), Mohammad Rahmati (Dahkki), Samaneh Ghasemali (Dahkki), Zohreh Sadeghi (Dahkki), Zahra Davoodi (Dahkki), Hossein Jafari Tekab (Dahkki), Masoud Gandomkar Ghalhar (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Tabriz University of Medical Sciences, 2014-03-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Purpose: Intensive chemotherapy with daunorubicin (DNR) is associated with serious side effects in acute myeloid leukemia (AML) patients. In this study the effect of small-molecule BH3-mimetic, ABT-737, on the sensitivity of HL60 and U937 AML cell lines was investigated. Methods: The cytotoxic effec...