ABT-737, Synergistically Enhances Daunorubicin-Mediated Apoptosis in Acute Myeloid Leukemia Cell Lines

• Автори: Hassan Dariushnejad (Автор), Nosratallah Zarghami (Автор), Mohammad Rahmati (Автор), Samaneh Ghasemali (Автор), Zohreh Sadeghi (Автор), Zahra Davoodi (Автор), Hossein Jafari Tekab (Автор), Masoud Gandomkar Ghalhar (Автор)
• Формат: Книга
• Опубліковано: Tabriz University of Medical Sciences, 2014-03-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Purpose: Intensive chemotherapy with daunorubicin (DNR) is associated with serious side effects in acute myeloid leukemia (AML) patients. In this study the effect of small-molecule BH3-mimetic, ABT-737, on the sensitivity of HL60 and U937 AML cell lines was investigated. Methods: The cytotoxic effec...