Pharmacokinetics and Pharmacodynamics of Antibody-Drug Conjugates Administered via Subcutaneous and Intratumoral Routes

We hypothesize that different routes of administration may lead to altered pharmacokinetics/pharmacodynamics (PK/PD) behavior of antibody-drug conjugates (ADCs) and may help to improve their therapeutic index. To evaluate this hypothesis, here we performed PK/PD evaluation for an ADC administered vi...

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Autores principales: Hsuan-Ping Chang (Autor), Huyen Khanh Le (Autor), Dhaval K. Shah (Autor)
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Publicado: MDPI AG, 2023-04-01T00:00:00Z.
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