Leishmania major infection in humanized mice induces systemic infection and provokes a nonprotective human immune response.

• Main Authors: Anja Kathrin Wege (Author), Christian Florian (Author), Wolfgang Ernst (Author), Nicole Zimara (Author), Ulrike Schleicher (Author), Frank Hanses (Author), Maximilian Schmid (Author), Uwe Ritter (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Leishmania (L.) species are the causative agent of leishmaniasis. Due to the lack of efficient vaccine candidates, drug therapies are the only option to deal with cutaneous leishmaniasis. Unfortunately, chemotherapeutic interventions show high toxicity in addition to an increased risk of...