Human Trypanosoma cruzi chronic infection leads to individual level steady-state parasitemia: Implications for drug-trial optimization in Chagas disease.

• Main Authors: Pablo M De Salazar (Author), Sergio Sosa-Estani (Author), Fernando Salvador (Author), Elena Sulleiro (Author), Adrián Sánchez-Montalvá (Author), Isabela Ribeiro (Author), Israel Molina (Author), Caroline O Buckee (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently available drugs against Trypanosoma cruzi infection, which causes 12000 deaths annually, have limitations in their efficacy, safety and tolerability. The evaluation of therapeutic responses to available and new compounds is based on parasite detection in the bloodstream but remains challen...