Pharmacokinetics, pharmacodynamics, safety and tolerability of cilofexor, a novel nonsteroidal Farnesoid X receptor agonist, in healthy volunteers

• मुख्य लेखकों: Islam R. Younis (लेखक), Brian J. Kirby (लेखक), Andrew N. Billin (लेखक), Deqing Xiao (लेखक), Qinghua Song (लेखक), Timothy R. Watkins (लेखक), Ahmed A. Othman (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Wiley, 2023-03-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Cilofexor is a nonsteroidal farnesoid X receptor (FXR) agonist being evaluated for treatment of nonalcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC). This work characterized the pharmacokinetics, pharmacodynamic, safety, and tolerability of cilofexor in healthy parti...