Influence of Probenecid on the Pharmacokinetics and Pharmacodynamics of Sorafenib

• Main Authors: Koen G. A. M. Hussaarts (Author), Leni van Doorn (Author), Karel Eechoute (Author), Jeffrey Damman (Author), Qiang Fu (Author), Nadia van Doorn (Author), Eric D. Eisenmann (Author), Alice A. Gibson (Author), Esther Oomen-de Hoop (Author), Peter de Bruijn (Author), Sharyn D. Baker (Author), Stijn L. W. Koolen (Author), Teun van Gelder (Author), Roelof W. F. van Leeuwen (Author), Ron H. J. Mathijssen (Author), Alex Sparreboom (Author), Sander Bins (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prior studies have demonstrated an organic anion transporter 6 (OAT6)-mediated accumulation of sorafenib in keratinocytes. The OAT6 inhibitor probenecid decreases sorafenib uptake in skin and might, therefore, decrease sorafenib-induced cutaneous adverse events. Here, the influence of probenecid on...