REGN1908‐1909 monoclonal antibodies block Fel d 1 in cat allergic subjects: Translational pharmacokinetics and pharmacodynamics

• Main Authors: Mohamed A. Kamal (Author), Robert Dingman (Author), Claire Q. Wang (Author), Ching‐Ha Lai (Author), Manoj Rajadhyaksha (Author), Michelle DeVeaux (Author), Jamie M. Orengo (Author), Allen Radin (Author), John D. Davis (Author)
• Format: Book
• Published: Wiley, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract REGN1908‐1909, a 1:1 cocktail of two fully human IgG4 monoclonal antibodies (mAbs), REGN1908 and REGN1909, is being evaluated for treatment of cat allergy. Both REGN1908 and REGN1909 bind to the dominant cat allergen, Fel d 1. Adults with cat allergy confirmed by skin prick test (SPT) were...