Systemic Effects of mitoTEMPO upon Lipopolysaccharide Challenge Are Due to Its Antioxidant Part, While Local Effects in the Lung Are Due to Triphenylphosphonium

• Main Authors: Adelheid Weidinger (Author), Linda Birgisdóttir (Author), Julia Schäffer (Author), Andras T. Meszaros (Author), Sergejs Zavadskis (Author), Andrea Müllebner (Author), Matthias Hecker (Author), Johanna Catharina Duvigneau (Author), Natascha Sommer (Author), Andrey V. Kozlov (Author)
• Format: Book
• Published: MDPI AG, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mitochondria-targeted antioxidants (mtAOX) are a promising treatment strategy against reactive oxygen species-induced damage. Reports about harmful effects of mtAOX lead to the question of whether these could be caused by the carrier molecule triphenylphosphonium (TPP). The aim of this study was to...