PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective
Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed. Given that MDM2 and p53 form an auto-regulatory loop, in which p53 undergoes targ...
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2022-05-01T00:00:00Z.
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