Random Insertion of mCherry Into VP3 Domain of Adeno-associated Virus Yields Fluorescent Capsids With no Loss of Infectivity

• Main Authors: Justin Judd (Author), Fang Wei (Author), Peter Q Nguyen (Author), Lawrence J Tartaglia (Author), Mavis Agbandje-McKenna (Author), Jonathan J Silberg (Author), Junghae Suh (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Adeno-associated virus (AAV)-derived vectors are promising gene delivery systems, and a number of design strategies have been pursued to improve their performance. For example, genetic insertion of proteins into the capsid may be used to achieve vector retargeting, reduced immunogenicity, or to trac...