Population pharmacokinetics and standard uptake value ratio of aducanumab, an amyloid plaque-removing agent, in patients with Alzheimer's disease

• Main Authors: Kumar Kandadi Muralidharan (Author), Xiao Tong (Author), Kenneth G. Kowalski (Author), Raj Rajagovindan (Author), Lin Lin (Author), Samantha Budd Haberlain (Author), Ivan Nestorov (Author)
• Format: Book
• Published: Wiley, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aducanumab is a human immunoglobulin G1 anti‐amyloid beta (Aβ) antibody currently being evaluated for potential treatment of patients with early Alzheimer's disease. This paper describes the relationship between the population pharmacokinetics (PopPKs) and pharmacokinetics‐pharmacodyna...