Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids with potential activity against VEGFR-2. The cytotoxic effects of the synthesised derivatives against Caco-2, HepG-2, and MDA-MB-231 c...

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Main Authors: Mohammed S. Taghour (Author), Hazem Elkady (Author), Wagdy M. Eldehna (Author), Nehal M. El-Deeb (Author), Ahmed M. Kenawy (Author), Eslam B. Elkaeed (Author), Aisha A. Alsfouk (Author), Mohamed S. Alesawy (Author), Ahmed M. Metwaly (Author), Ibrahim. H. Eissa (Author)
Format: Book
Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
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