Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies

• Principais autores: Mohammed S. Taghour (Autor), Hazem Elkady (Autor), Wagdy M. Eldehna (Autor), Nehal M. El-Deeb (Autor), Ahmed M. Kenawy (Autor), Eslam B. Elkaeed (Autor), Aisha A. Alsfouk (Autor), Mohamed S. Alesawy (Autor), Ahmed M. Metwaly (Autor), Ibrahim. H. Eissa (Autor)
• Formato: Livro
• Publicado em: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new hybrids with potential activity against VEGFR-2. The cytotoxic effects of the synthesised derivatives against Caco-2, HepG-2, and MDA-MB-231 c...