IFN-β mediates the anti-osteoclastic effect of bisphosphonates and dexamethasone

• Main Authors: Prajakta Kalkar (Author), Gal Cohen (Author), Tal Tamari (Author), Sagie Schif-Zuck (Author), Hadar Zigdon-Giladi (Author), Amiram Ariel (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zoledronic acid (Zol) is a potent bisphosphonate that inhibits the differentiation of monocytes into osteoclasts. It is often used in combination with dexamethasone (Dex), a glucocorticoid that promotes the resolution of inflammation, to treat malignant diseases, such as multiple myeloma. This treat...