Neonatal overfeeding during lactation rapidly and permanently misaligns the hepatic circadian rhythm and programmes adult NAFLD

• Main Authors: Francesc Ribas-Aulinas (Author), Silvia Ribo (Author), Marcela Parra-Vargas (Author), Antonio Fernández-Pérez (Author), Judith Cebrià (Author), Maria Guardiola-Perello (Author), Marta Ramon-Krauel (Author), Carles Lerin (Author), Ruben Diaz (Author), Susana G. Kalko (Author), Mario Vallejo (Author), Antoni Díez-Noguera (Author), Trinitat Cambras (Author), Josep C. Jimenez-Chillaron (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. The mechanisms that link early adiposity with late-onset chronic diseases are poorly characterised. We developed a mouse model of early adiposity through litter size reduction. Mice reared in sm...