Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

• প্রধান লেখক: Giulio Poli (লেখক), Margherita Lapillo (লেখক), Carlotta Granchi (লেখক), Jessica Caciolla (লেখক), Nayla Mouawad (লেখক), Isabella Caligiuri (লেখক), Flavio Rizzolio (লেখক), Thierry Langer (লেখক), Filippo Minutolo (লেখক), Tiziano Tuccinardi (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Fyn tyrosine kinase inhibitors are considered potential therapeutic agents for a variety of human cancers. Furthermore, the involvement of Fyn kinase in signalling pathways that lead to severe pathologies, such as Alzheimer's and Parkinson's diseases, has also been demonstrated. In this st...