Discovery of a Novel Template, 7-Substituted 7-Deaza-4'-Thioadenosine Derivatives as Multi-Kinase Inhibitors

• Main Authors: Karishma K. Mashelkar (Author), Woong Sub Byun (Author), Hyejin Ko (Author), Kisu Sung (Author), Sushil K. Tripathi (Author), Seungchan An (Author), Yun A Yum (Author), Jee Youn Kwon (Author), Minjae Kim (Author), Gibae Kim (Author), Eun-Ji Kwon (Author), Hyuk Woo Lee (Author), Minsoo Noh (Author), Sang Kook Lee (Author), Lak Shin Jeong (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of anticancer drugs remains challenging owing to the potential for drug resistance. The simultaneous inhibition of multiple targets involved in cancer could overcome resistance, and these agents would exhibit higher potency than single-target inhibitors. Protein kinases represent a p...