Tumour‐derived leukaemia inhibitory factor is a major driver of cancer cachexia and morbidity in C26 tumour‐bearing mice

• Main Authors: Susan C. Kandarian (Author), Rachel L. Nosacka (Author), Andrea E. Delitto (Author), Andrew R. Judge (Author), Sarah M. Judge (Author), John D. Ganey (Author), Jesse D. Moreira (Author), Robert W. Jackman (Author)
• Format: Book
• Published: Wiley, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Cancer cachexia is a metabolic wasting syndrome that is strongly associated with a poor prognosis. The initiating factors causing fat and muscle loss are largely unknown. Previously, we found that leukaemia inhibitory factor (LIF) secreted by C26 colon carcinoma cells was respons...