Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives as α-glucosidase and α-amylase inhibitors

• Main Authors: Xu-Yang Deng (Author), Jun-Jie Ke (Author), Ying-Ying Zheng (Author), Dong-Li Li (Author), Kun Zhang (Author), Xi Zheng (Author), Jing-Ying Wu (Author), Zhuang Xiong (Author), Pan-Pan Wu (Author), Xue-Tao Xu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Different oleanolic acid (OA) oxime ester derivatives (3a-3t) were designed and synthesised to develop inhibitors against α-glucosidase and α-amylase. All the synthesised OA derivatives were evaluated against α-glucosidase and α-amylase in vitro. Among them, compound 3a showed the highest α-glucosid...