Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice

• Main Authors: Jing Liu (Author), Wencai Li (Author), Manoj H. Limbu (Author), Yiping Li (Author), Zhi Wang (Author), Zhengyuan Cheng (Author), Xiaoyi Zhang (Author), Pingsheng Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aim: To investigate whether double-knockdown of PHD1 and Keap1 in mice could enhance the resolution of carbon tetrachloride (CCl4)-induced liver fibrosis.Methods: The liver fibrosis model of mice was established by intraperitoneal injection of 25% CCl4 in olive oil (4 ul/g) twice a we...