Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, "UCAA-motif" RNA Aptamers

• मुख्य लेखकों: Angela S Whatley (लेखक), Mark A Ditzler (लेखक), Margaret J Lange (लेखक), Elisa Biondi (लेखक), Andrew W Sawyer (लेखक), Jonathan L Chang (लेखक), Joshua D Franken (लेखक), Donald H Burke (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2013-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

RNA aptamers that bind the reverse transcriptase (RT) of human immunodeficiency virus (HIV) compete with nucleic acid primer/template for access to RT, inhibit RT enzymatic activity in vitro, and suppress viral replication when expressed in human cells. Numerous pseudoknot aptamers have been identif...