Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, "UCAA-motif" RNA Aptamers

• Main Authors: Angela S Whatley (Author), Mark A Ditzler (Author), Margaret J Lange (Author), Elisa Biondi (Author), Andrew W Sawyer (Author), Jonathan L Chang (Author), Joshua D Franken (Author), Donald H Burke (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA aptamers that bind the reverse transcriptase (RT) of human immunodeficiency virus (HIV) compete with nucleic acid primer/template for access to RT, inhibit RT enzymatic activity in vitro, and suppress viral replication when expressed in human cells. Numerous pseudoknot aptamers have been identif...