Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

• Egile Nagusiak: Belal Almajali (Egilea), Muhammad Farid Johan (Egilea), Abdullah Saleh Al-Wajeeh (Egilea), Wan Rohani Wan Taib (Egilea), Imilia Ismail (Egilea), Maysa Alhawamdeh (Egilea), Nafe M. Al-Tawarah (Egilea), Wisam Nabeel Ibrahim (Egilea), Futoon Abedrabbu Al-Rawashde (Egilea), Hamid Ali Nagi Al-Jamal (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator pathways could be targeted instead. This study investigated the effects of thymoq...