Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells

Overexpression of c-Myc plays an essential role in leukemogenesis and drug resistance, making c-Myc an attractive target for cancer therapy. However, targeting c-Myc directly is impossible, and c-Myc upstream regulator pathways could be targeted instead. This study investigated the effects of thymoq...

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Main Authors: Belal Almajali (Author), Muhammad Farid Johan (Author), Abdullah Saleh Al-Wajeeh (Author), Wan Rohani Wan Taib (Author), Imilia Ismail (Author), Maysa Alhawamdeh (Author), Nafe M. Al-Tawarah (Author), Wisam Nabeel Ibrahim (Author), Futoon Abedrabbu Al-Rawashde (Author), Hamid Ali Nagi Al-Jamal (Author)
Format: Book
Published: MDPI AG, 2022-03-01T00:00:00Z.
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