Recombinant Ricin Toxin Binding Subunit B (RTB) Stimulates Production of TNF-α by Mouse Macrophages Through Activation of TLR4 Signaling Pathway

• Main Authors: Na Xu (Author), Kaikai Yu (Author), Haotian Yu (Author), Jianxu Zhang (Author), Yang Yang (Author), Mingxin Dong (Author), Yan Wang (Author), Ying Chang (Author), Yucheng Sun (Author), Yanguang Hou (Author), Chengbiao Sun (Author), Jiayu Wan (Author), Wensen Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ricin toxin binding subunit B (RTB) is a galactose-binding lectin protein derived from the beans of the castor oil plant (Ricinus communis). Our previous studies have reported a direct immunomodulatory effect of recombinant RTB, which stimulates RAW264.7 cells to produce cytokines including TNF-α. H...