Oxidative Stress Is Associated with Neuroinflammation in Animal Models of HIV-1 Tat Neurotoxicity

• প্রধান লেখক: Jean-Pierre Louboutin (Author), Lokesh Agrawal (Author), Beverly A. S. Reyes (Author), Elisabeth J. Van Bockstaele (Author), David S. Strayer (Author)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2014-05-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

HIV-1 trans-acting protein Tat, an essential protein for viral replication, is a key mediator of neurotoxicity. If Tat oxidant injury and neurotoxicity have been described, consequent neuroinflammation is less understood. Rat caudate-putamens (CPs) were challenged with Tat, with or without prior rSV...