Cytotoxicity evaluation of haloperidol, clozapine and a new molecule with antipsychotic potential, PT-31, in NIH-3T3 cells

• Main Authors: Juliana Machado Kayser (Author), Gabriela Zimmermann Prado Rodrigues (Author), Carlos Henrique Thomazi (Author), Alana Witt Hansen (Author), Marina Griebeler Moreira (Author), Marina Galdino da Rocha Pitta (Author), Ivan da Rocha Pitta (Author), Ana Luiza Ziulkoski (Author), Andresa Heemann Betti (Author)
• Format: Book
• Published: Universidade de São Paulo, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Schizophrenia is an illness that affects 26 million people worldwide. However, conventional antipsychotics present side effects and toxicity, highlighting the need for new antipsychotics. We aimed to evaluate the cytotoxicity of haloperidol (HAL), clozapine (CLO), and a new molecule with an...