Superoxide-Mediated Upregulation of MMP9 Participates in BMPR2 Destabilization and Pulmonary Hypertension Development

• Principais autores: Norah Alruwaili (Autor), Sharath Kandhi (Autor), Ghezal Froogh (Autor), Melissa R. Kelly (Autor), Dong Sun (Autor), Michael S. Wolin (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2023-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background and Aims: we previously reported in studies on organoid-cultured bovine pulmonary arteries that pulmonary hypertension (PH) conditions of exposure to hypoxia or endothelin-1 caused a loss of a cartilage oligomeric matrix protein (COMP) stabilization of bone morphogenetic protein receptor-...