Relaxin/insulin-like family peptide receptor 4 (Rxfp4) expressing hypothalamic neurons modulate food intake and preference in mice

• Main Authors: Jo E. Lewis (Author), Orla RM. Woodward (Author), Danaé Nuzzaci (Author), Christopher A. Smith (Author), Alice E. Adriaenssens (Author), Lawrence Billing (Author), Cheryl Brighton (Author), Benjamin U. Phillips (Author), John A. Tadross (Author), Sarah J. Kinston (Author), Ernesto Ciabatti (Author), Berthold Göttgens (Author), Marco Tripodi (Author), David Hornigold (Author), David Baker (Author), Fiona M. Gribble (Author), Frank Reimann (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Insulin-like peptide 5 (INSL5) signalling, through its cognate receptor relaxin/insulin-like family peptide receptor 4 (RXFP4), has been reported to be orexigenic, and the high fat diet (HFD) preference observed in wildtype mice is altered in Rxfp4 knock-out mice. In this study, we used a...