High-fat diet combined with dextran sulfate sodium failed to induce a more serious NASH phenotype than high-fat diet alone

• Main Authors: Yan Zhou (Author), Ya Feng (Author), Lili Yang (Author), Peiyong Zheng (Author), Lu Hang (Author), Fengru Jiang (Author), Jianye Yuan (Author), Lixin Zhu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Aims: Animal models are essential tools to investigate the pathogenesis of diseases. Disruption in the intestinal epithelial barrier and gut vascular barrier is an early event in the development of non-alcoholic fatty liver disease (NAFLD). Intestinal epithelial barrier can be destroy...