Simulated rat intestinal fluid improves oral exposure prediction for poorly soluble compounds over a wide dose range

• Những tác giả chính: Joerg Berghausen (Tác giả), Frank Hans Seiler (Tác giả), Nathalie Gobeau (Tác giả), Bernard Faller (Tác giả)
• Định dạng: Sách
• Được phát hành: International Association of Physical Chemists (IAPC), 2016-03-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Solubility can be the absorption limiting factor for drug candidates and is therefore a very important input parameter for oral exposure prediction of compounds with limited solubility. Biorelevant media of the fasted and fed state have been published for humans, as well as for dogs in the fasted st...