Metformin Inhibits NLR Family Pyrin Domain Containing 3 (NLRP)-Relevant Neuroinflammation via an Adenosine-5'-Monophosphate-Activated Protein Kinase (AMPK)-Dependent Pathway to Alleviate Early Brain Injury After Subarachnoid Hemorrhage in Mice

• Main Authors: Lei Jin (Author), Fa Jin (Author), Shenquan Guo (Author), Wenchao Liu (Author), Boyang Wei (Author), Haiyan Fan (Author), Guangxu Li (Author), Xin Zhang (Author), Shixing Su (Author), Ran Li (Author), Dazhao Fang (Author), Chuanzhi Duan (Author), Xifeng Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroinflammation plays a key role in the pathogenesis of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Previous studies have shown that metformin exerts anti-inflammatory effects and promotes functional recovery in various central nervous system diseases. We designed this study to i...