Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

• Asıl Yazarlar: Masako Sasaki (Yazar), Ikuo Miyahisa (Yazar), Sachiko Itono (Yazar), Hiroaki Yashiro (Yazar), Hideyuki Hiyoshi (Yazar), Kazue Tsuchimori (Yazar), Ken‐ichi Hamagami (Yazar), Yusuke Moritoh (Yazar), Masanori Watanabe (Yazar), Kimio Tohyama (Yazar), Minoru Sasaki (Yazar), Jun‐ichi Sakamoto (Yazar), Tomohiro Kawamoto (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wiley, 2019-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abstract Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery and pharmacological profiles of SCO‐792, a novel i...