Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

Discovery and characterization of a small‐molecule enteropeptidase inhibitor, SCO‐792

Abstract Enteropeptidase, localized into the duodenum brush border, is a key enzyme catalyzing the conversion of pancreatic trypsinogen proenzyme to active trypsin, thereby regulating protein digestion and energy homeostasis. We report the discovery and pharmacological profiles of SCO‐792, a novel i...

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Main Authors: Masako Sasaki (Author), Ikuo Miyahisa (Author), Sachiko Itono (Author), Hiroaki Yashiro (Author), Hideyuki Hiyoshi (Author), Kazue Tsuchimori (Author), Ken‐ichi Hamagami (Author), Yusuke Moritoh (Author), Masanori Watanabe (Author), Kimio Tohyama (Author), Minoru Sasaki (Author), Jun‐ichi Sakamoto (Author), Tomohiro Kawamoto (Author)
Format: Book
Published: Wiley, 2019-10-01T00:00:00Z.
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3rd Floor Main Library

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