Mixed effects modeling of radiotherapy in combination with immune checkpoint blockade or inhibitors of the DNA damage response pathway

• Main Authors: David Hodson (Author), Hitesh Mistry (Author), Sofia Guzzetti (Author), Michael Davies (Author), Anna Staniszewska (Author), Paul Farrington (Author), Elaine Cadogan (Author), James Yates (Author), Leon Aarons (Author), Kayode Ogungbenro (Author)
• 格式: 圖書
• 出版: Wiley, 2023-11-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Abstract Dosage optimization to maximize efficacy and minimize toxicity is a potential issue when administering radiotherapy (RT) in combination with immune checkpoint blockade (ICB) or inhibitors of the DNA Damage Response Pathway (DDRi) in the clinic. Preclinical models and mathematical modeling c...