Sustained Interleukin-1β Exposure Modulates Multiple Steps in Glucocorticoid Receptor Signaling, Promoting Split-Resistance to the Transactivation of Prominent Anti-Inflammatory Genes by Glucocorticoids

• Asıl Yazarlar: Pedro Escoll (Yazar), Ismael Ranz (Yazar), Norman Muñoz-Antón (Yazar), Ana van- (Yazar), Melchor Alvarez-Mon (Yazar), Carlos Martínez-Alonso (Yazar), Eva Sanz (Yazar), Antonio de- (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Hindawi Limited, 2015-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Clinical treatment with glucocorticoids (GC) can be complicated by cytokine-induced glucocorticoid low-responsiveness (GC-resistance, GCR), a condition associated with a homogeneous reduction in the expression of GC-receptor- (GR-) driven anti-inflammatory genes. However, GR level and phosphorylatio...