An accelerated surface-mediated stress assay of antibody instability for developability studies

• Main Authors: Marie R.G. Kopp (Author), Adriana-Michelle Wolf Pérez (Author), Marta Virginia Zucca (Author), Umberto Capasso Palmiero (Author), Brigitte Friedrichsen (Author), Nikolai Lorenzen (Author), Paolo Arosio (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High physical stability is required for the development of monoclonal antibodies (mAbs) into successful therapeutic products. Developability assays are used to predict physical stability issues such as high viscosity and poor conformational stability, but protein aggregation remains a challenging pr...