A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

• Main Authors: Xiaohua Xu (Author), Aleksandar Denic (Author), Luke R. Jordan (Author), Nathan J. Wittenberg (Author), Arthur E. Warrington (Author), Bharath Wootla (Author), Louisa M. Papke (Author), Laurie J. Zoecklein (Author), Daehan Yoo (Author), Jonah Shaver (Author), Sang-Hyun Oh (Author), Larry R. Pease (Author), Moses Rodriguez (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neurological disease that primarily affects spinal cord anterior horn cells and their axons for which there is no treatment. Here we report the use of a recombinant natural human IgM that binds to the surface of neurons and supports neurite...