Pancreatic melatonin enhances anti-tumor immunity in pancreatic adenocarcinoma through regulating tumor-associated neutrophils infiltration and NETosis

• Main Authors: Yau-tuen Chan (Author), Hor-yue Tan (Author), Yuanjun Lu (Author), Cheng Zhang (Author), Chien-shan Cheng (Author), Junyu Wu (Author), Ning Wang (Author), Yibin Feng (Author)
• Format: Book
• Published: Elsevier, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tumor microenvironment contributes to poor prognosis of pancreatic adenocarcinoma (PAAD) patients. Proper regulation could improve survival. Melatonin is an endogenous hormone that delivers multiple bioactivities. Here we showed that pancreatic melatonin level is associated with patients' survi...