In Vitro Activity of a Novel Siderophore-Cephalosporin, GT-1 and Serine-Type β-Lactamase Inhibitor, GT-055, against <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i> and <i>Acinetobacter</i> spp. Panel Strains

• Hoofdauteurs: Le Phuong Nguyen (Auteur), Naina Adren Pinto (Auteur), Thao Nguyen Vu (Auteur), Hyunsook Lee (Auteur), Young Lag Cho (Auteur), Jung-Hyun Byun (Auteur), Roshan D'Souza (Auteur), Dongeun Yong (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-05-01T00:00:00Z.
• Onderwerpen: article
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This study investigates GT-1 (also known as LCB10-0200), a novel-siderophore cephalosporin, inhibited multidrug-resistant (MDR) Gram-negative pathogen, via a Trojan horse strategy exploiting iron-uptake systems. We investigated GT-1 activity and the role of siderophore uptake systems, and the combin...