Chronic Administration of COVID-19 Drugs Fluvoxamine and Lopinavir Shortens Action Potential Duration by Inhibiting the Human Ether‐à‐go‐go-Related Gene and Cav1.2

• Main Authors: Zequn Zheng (Author), Dihui Cai (Author), Yin Fu (Author), Ying Wang (Author), Yongfei Song (Author), Jiangfang Lian (Author)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Background: Old drugs for new indications in the novel coronavirus disease of 2019 (COVID-19) pandemic have raised concerns regarding cardiotoxicity, especially the development of drug-induced QT prolongation. The acute blocking of the cardiac hERG potassium channel is conventionally thought to be t...