Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation

• Main Authors: Bruce Ng (Author), Tanesha Cash-Mason (Author), Yi Wang (Author), Jessica Seitzer (Author), Julja Burchard (Author), Duncan Brown (Author), Vadim Dudkin (Author), Joseph Davide (Author), Vasant Jadhav (Author), Laura Sepp-Lorenzino (Author), Pedro J. Cejas (Author)
• Format: Book
• Published: Elsevier, 2019-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Clinical application of siRNA-based therapeutics outside of the liver has been hindered by the inefficient delivery of siRNA effector molecules into extra-hepatic organs and cells of interest. To understand the parameters that enable RNAi activity in vivo, it is necessary to develop a systematic app...