Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme

• Main Authors: Rosario Rullo (Author), Carmen Cerchia (Author), Rosarita Nasso (Author), Virgilio Romanelli (Author), Emmanuele De Vendittis (Author), Mariorosario Masullo (Author), Antonio Lavecchia (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species. Altered functions of XO may lead to severe pathological diseases, including gout-causing hyperuricemia and oxidative damage of t...