Novel Reversible Inhibitors of Xanthine Oxidase Targeting the Active Site of the Enzyme

• Главные авторы: Rosario Rullo (Автор), Carmen Cerchia (Автор), Rosarita Nasso (Автор), Virgilio Romanelli (Автор), Emmanuele De Vendittis (Автор), Mariorosario Masullo (Автор), Antonio Lavecchia (Автор)
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• Опубликовано: MDPI AG, 2023-03-01T00:00:00Z.
• Предметы: article
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Xanthine oxidase (XO) is a flavoprotein catalysing the oxidation of hypoxanthine to xanthine and then to uric acid, while simultaneously producing reactive oxygen species. Altered functions of XO may lead to severe pathological diseases, including gout-causing hyperuricemia and oxidative damage of t...