Cancer apelin receptor suppresses vascular mimicry in malignant melanoma

• Main Authors: Koichi Inukai (Author), Kazuyoshi Kise (Author), Yumiko Hayashi (Author), Weizhen Jia (Author), Fumitaka Muramatsu (Author), Naoki Okamoto (Author), Hirotaka Konishi (Author), Keigo Akuta (Author), Hiroyasu Kidoya (Author), Nobuyuki Takakura (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Several reports indicate that apelin is often over-expressed in tumors, and therefore it has been suggested that the apelin-apelin receptor (APJ) system may induce tumor progression. In contrast, our previous research revealed high expression of the apelin-APJ system in tumor blood vessels, suggesti...