Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

• Main Authors: Jia Wen (Author), Xiuge Gao (Author), Qian Zhang (Author), Benazir Sahito (Author), Hongbin Si (Author), Gonghe Li (Author), Qi Ding (Author), Wenda Wu (Author), Eugenie Nepovimova (Author), Shanxiang Jiang (Author), Liping Wang (Author), Kamil Kuca (Author), Dawei Guo (Author)
• Format: Book
• Published: MDPI AG, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tilmicosin (TMS) is widely used to treat bacterial infections in veterinary medicine, but the clinical effect is limited by its poor solubility, bitterness, gastric instability, and intestinal efflux transport. Nanostructured lipid carriers (NLCs) are nowadays considered to be a promising vector of...