pH-Responsive Alginate-Based Microparticles for Colon-Targeted Delivery of Pure Cyclosporine A Crystals to Treat Ulcerative Colitis

• Autores principales: Murtada A. Oshi (Autor), Juho Lee (Autor), Jihyun Kim (Autor), Nurhasni Hasan (Autor), Eunok Im (Autor), Yunjin Jung (Autor), Jin-Wook Yoo (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-09-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Cyclosporine A (CsA) is a potent immunosuppressant for treating ulcerative colitis (UC). However, owing to severe systemic side effects, CsA application in UC therapy remains limited. Herein, a colon-targeted drug delivery system consisting of CsA crystals (CsAc)-loaded, Eudragit S 100 (ES)-coated a...