DC-SIGN (CD209) Promoter -336 A/G polymorphism is associated with dengue hemorrhagic fever and correlated to DC-SIGN expression and immune augmentation.

• Main Authors: Lin Wang (Author), Rong-Fu Chen (Author), Jien-Wei Liu (Author), Ing-Kit Lee (Author), Chiu-Ping Lee (Author), Ho-Chang Kuo (Author), Shau-Ku Huang (Author), Kuender D Yang (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: the C-type lectin DC-SIGN (CD209) is known to be the major dengue receptor on human dendritic cells, and a single nucleotide polymorphism (SNP) in the promoter region of CD209 (-336 A/G; rs4804803) is susceptible to many infectious diseases. We reason that variations in the DC-SIGN gene...