Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

• Main Authors: Lei Liu (Author), Xin-Lu Pang (Author), Wen-Jun Shang (Author), Hong-Chang Xie (Author), Jun-Xiang Wang (Author), Gui-Wen Feng (Author)
• פורמט: ספר
• יצא לאור: BMC, 2018-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Abstract Background MicroRNAs (miRNAs) contribute to the progression of chronic kidney disease (CKD) by regulating renal homeostasis. This study explored the effects of miR-181a on CKD through the Toll-like receptor (TLR)/nuclear factor-kappa B (NF-κB) pathway by binding to CRY1. Methods Seventy mal...