The anti-fibrotic effect of inhibition of TGFβ-ALK5 signalling in experimental pulmonary fibrosis in mice is attenuated in the presence of concurrent γ-herpesvirus infection

• Main Authors: Natalia Smoktunowicz (Author), Robert E. Alexander (Author), Linda Franklin (Author), Andrew E. Williams (Author), Beverley Holman (Author), Paul F. Mercer (Author), Gabor Jarai (Author), Chris J. Scotton (Author), Rachel C. Chambers (Author)
• Format: Book
• Published: The Company of Biologists, 2015-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

TGFβ-ALK5 pro-fibrotic signalling and herpesvirus infections have been implicated in the pathogenesis and exacerbation of pulmonary fibrosis. In this study we addressed the role of TGFβ-ALK5 signalling during the progression of fibrosis in a two-hit mouse model of murine γ-herpesvirus 68 (MHV-68) in...