The enemy within: Targeting host-parasite interaction for antileishmanial drug discovery.

• Main Authors: Suzanne Lamotte (Author), Gerald F Späth (Author), Najma Rachidi (Author), Eric Prina (Author)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The state of antileishmanial chemotherapy is strongly compromised by the emergence of drug-resistant Leishmania. The evolution of drug-resistant phenotypes has been linked to the parasites' intrinsic genome instability, with frequent gene and chromosome amplifications causing fitness gains that...