Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

• मुख्य लेखकों: Amruta S Mhashilkar (लेखक), Sai L Vankayala (लेखक), Canhui Liu (लेखक), Fiona Kearns (लेखक), Priyanka Mehrotra (लेखक), George Tzertzinis (लेखक), Subba R Palli (लेखक), H Lee Woodcock (लेखक), Thomas R Unnasch (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets. METHODOLOGY/ PRINCIPAL FINDINGS:Admini...