Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

• Main Authors: Amruta S Mhashilkar (Author), Sai L Vankayala (Author), Canhui Liu (Author), Fiona Kearns (Author), Priyanka Mehrotra (Author), George Tzertzinis (Author), Subba R Palli (Author), H Lee Woodcock (Author), Thomas R Unnasch (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets. METHODOLOGY/ PRINCIPAL FINDINGS:Admini...