Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

Identification of Ecdysone Hormone Receptor Agonists as a Therapeutic Approach for Treating Filarial Infections.

BACKGROUND:A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets. METHODOLOGY/ PRINCIPAL FINDINGS:Admini...

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Main Authors: Amruta S Mhashilkar (Author), Sai L Vankayala (Author), Canhui Liu (Author), Fiona Kearns (Author), Priyanka Mehrotra (Author), George Tzertzinis (Author), Subba R Palli (Author), H Lee Woodcock (Author), Thomas R Unnasch (Author)
Format: Book
Published: Public Library of Science (PLoS), 2016-06-01T00:00:00Z.
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