Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

• Main Authors: Tianyuan Yang (Author), Xiujing Feng (Author), Yuan Zhao (Author), Haiyang Zhang (Author), Hailin Cui (Author), Mian Wei (Author), Haotian Yang (Author), Honggang Fan (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

BackgroundAcute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a proce...