Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

• Egile Nagusiak: Tianyuan Yang (Egilea), Xiujing Feng (Egilea), Yuan Zhao (Egilea), Haiyang Zhang (Egilea), Hailin Cui (Egilea), Mian Wei (Egilea), Haotian Yang (Egilea), Honggang Fan (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

BackgroundAcute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a proce...